Alzheimer's

Keeping your Mind Sharp! 

Alzheimer’s, Memory Loss, Cognitive Decline and Dementia. 

by Dr. John Clark     www.NorthernLightsHealthEducation.com 


Her absence initially sounded no alarm; everyone thought she was with someone else. But as twilight fell, and Mrs. Parker didn’t show up, fears mounted. Six weeks of intensive searching and national news coverage failed to locate the missing retiree. What had happened? Plagued with the failing memory and disorientation of advancing Alzheimer’s, Mrs. Parker had wondered off, not to be discovered till 6 month later, 13 miles (20 km) from home where she had been overcome with exposure.

What is dementia? It is a progressive decline in brain function—brain failure if you please--loss of memory, intellect, rationality, social skills and physical functioning. It is an illness that can happen to anybody, but it is more common as one gets older. Statistically it is more common after age 65, at which age as many as one in ten people come down with it. By 85 years of age fully one in three individuals will meet the criteria.1 Sixty percent of people have personal fear of developing Alzheimer’s.2

The most common types of dementia are Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal Lobar Degeneration, Huntington's disease, alcohol related dementia (Korsakoff's syndrome) and Creutzfeldt-Jacob disease (mad cows disease in humans).3 For our purposes, to keep things simple, and to focus largely on the predominant form--Alzheimer’s--I will refer collectively to these diseases with the words Alzheimer’s and/or Dementia.

Who gets dementia? In Australia, dementia is the second leading cause of death, superseded only by heart disease.4 For women it is the leading cause of death, surpassing even breast cancer, lung cancer, heart disease and stroke.

What happens to a person’s brain in Alzheimer’s Disease? Two distinctive findings in the brains of patients with Alzheimer’s disease confirm the diagnosis and contribute to its disease process. The first is the appearance and accumulation of a degenerate protein named amyloid into formations called plaques found between the brain cells. The second is the appearance of twisted mats of fibers within the brain cells themselves called neurofibrillary tangles which are made up of a protein called tau.5 So when we talk of lifestyle practices that increase Amyloid or neurofibrillary tangles, you know we are talking about things that increase Alzheimer’s or dementia.

Alzheimer's disease typically progresses slowly in three general stages — mild (early-stage), moderate (middle-stage), and severe (late-stage).6 Alzheimer's disease typically progresses slowly. Different people progress at different rates. Most die within 4-8 years of its onset.7

How could a person determine if they were coming down with dementia or Alzheimer’s? There are ten well accepted signs to consider:8

Memory loss that disrupts daily life.

Challenges in planning or solving problems.

Difficulty completing familiar tasks at home, at work or at leisure. Confusion with time or place.

Trouble understanding visual images and spatial relationships. New problems with words in speaking or writing.

Misplacing things and losing the ability to retrace steps.

Decreased or poor judgment. Withdrawal from work or social activities. Changes in mood and personality.

At this point, how many feel like they are doomed to dementia? As you reviewed this list, did you find yourself feeling uncomfortable as some of the signs struck close to home? Don’t wait till you have all the signs of Alzheimer’s before deciding to do something positive for your future mental health. Would you like to know what causes dementia and what you can do to avoid or even reverse it?

So, what causes Alzheimer’s and dementia? Topping the list of lifestyle practices you need to avoid if you want to keep your mind sharp and avoid Alzheimer’s is overeating. And why overeating? Overeating decreases your brains blood flow9 and oxygen while increasing its inflammation10 and its Alzheimer’s β-amyloid protein.11

On the other hand, Okanawans, as a group of people, are less likely to get Dementia. Any idea why? One very important reason is that they eat, on average 40% fewer calories.12 Indeed, caloric restriction and intermittent fasting has been shown to significantly reduce your risk of Alzheimer’s.13 And why is eating less so helpful? One way it helps is that it increases your key antioxidant defense enzymes.14 Additionally it Increases your brain-derived neurotrophic factor (BDNF), a molecule which helps your brain to grow and stay young. Caloric restriction also stimulates the growth of new neurons from stem cells.15


One practical way to practice caloric restriction is to eat only two meals a day, well-spaced apart, instead of three.16 This means no snacking. Don’t eat between meals; the pleasure of doing so will eventually be forgotten. If you maintain a regular meal schedule17 of two or three daily meals with no snacking between, it has an anti-ageing effect on your brain.


With overeating having such a detrimental effect on brain health, would it be of any surprise to you to discover that obesity is a huge risk factor for dementia? Indeed, being over weight increases your risk of Alzheimer’s by 60%.18 Obesity, when combined, as it often is, with diabetes, quadruples the risk of Dementia.19

Can you think of some ways in which you could make eating fewer calories palatable and satisfying while maintaining the health of your brain?

Not that we want you to stop eating all together, that is not the goal. That said, some foods are beneficial for your brain while others aren’t. Meat is particularly hazardous to long term mental abilities due to its negative impact on brain inflammation.20,21,22 This holds true also of a diet overly rich in fats, as fatty foods, fried foods and cooking oils. For this reason fried foods, especially fried meats, are best left off the Alzheimer’s prevention diet. This holds true for high or “full” fat dairy products as well.23

Not all fats are created equal. Some fats pose a greater danger than others. Saturated fats and trans-fats in your diet accelerate cognitive deterioration and are associated with cognitive decline among older persons.24

Inflammation is a danger to one’s brain. One mechanism by which diet contributes to decline in mental functioning is its contribution to inflammation in the brain.25 Inflammation is increased by fermented foods because fermentation generates aflatoxins, and aflatoxins weaken your memory.26 Examples of fermented foods include: cheese, vinegar, alcohol, soy sauce, chocolate, coffee, vanilla, brown rice syrup, etc. Eating fresh food is much preferable to old, aged spoiled foods.

Sugar is hazardous to brain longevity. Any food that would give a diabetic high blood sugar, such as refined carbohydrates and sugar, will increase your risk of dementia.27,28 Sugar clogs the system and decreases your memory function.29 Add milk and it gets even worse. Higher intakes of dairy desserts and ice-cream cause even more rapid cognitive decline.30

What happens if you feed normally vegetarian animals dietary cholesterol? For rabbits, this spells Alzheimer’s changes in their brains—forget carnivore rabbits!31 Meat eaters suffer three time the risk of dementia as vegetarians. And why is that? A recent study links up to 13% of all "Alzheimer's" victims as really having Creutzfeldt-Jakob disease or mad cow disease. Which brings up the unthinkable: that Alzheimer's, Cruetzfeldt-Jackob, and Mad Cow Disease might just be caused by eating contaminated meat or dairy.32


At this point, let me pause to let you take a moment to think back over your life and all the food you have eaten, and consider; have your dietary choices been nurturing to brain health or have they tended toward brain degeneration? What can you do at this point to improve your long-term chances of avoiding Alzheimer’s?


Believe it or not, brain health is closely connected with colon health. Why? Microbes in your digestive tract effect the health of your brain through molecules they release into your blood circulation. The diet you choose profoundly affects the bacteria that can survive in your gut. The brain suffers when the wrong diet favours the harmful bacteria.33 The western diet supports an intestinal bacterial population (or “microbiome”, as it has come to be called) that increases the risk of dementia.34

Gut bacteria are not the only microbes that impact your mental status. There are many microorganisms, some good and some not so good that are capable of having a telling influence on the long-term wellbeing of your brain. Dangerous microorganisms are frequently associated with degeneration, decay, fermentation, spoilage, the rotting process, aging and infections. For example, if your home has experienced water damage, moulds and mycotoxins will be present which will in turn compromise your mental functioning.35 By the same token, letting the same organisms responsible for the deterioration of your living quarters live in your food can have the same dangerous effect. At this point the important question to be asked is, do any of my foods contain mycotoxins, such as aflatoxin? A little research will reveal what commonly eaten foods have fermentation as part of their processing. Some common ones include: wine, vinegar, cheese, yogurt, sauerkraut, soy sauce, brown rice syrup, miso, Tempe, coffee, black tea, vanilla, yeast, mushrooms, salami, etc. Fermentation is not a way to make your food better, but to introduce into it the toxic waste products of microorganisms.36,37 Some foods, because of their storage or harvesting conditions are more likely to contain aflatoxins, one such example is peanuts and peanut butter.38

Mono Sodium Glutamate (MSG) increases Alzheimer’s degenerative changes in your brain. How do you give laboratory rats Alzheimer’s so that you can study them? One common technique is to put MSG in their food.39 How do you give people Alzheimer’s? MSG increases both amyloid40 and tau41 Alzheimer’s proteins in the brain leading to plaque formation and neurofibrillary tangles. Read your labels! Where do you find MSG? It’s hidden under a lot of names in foods, and a lot of ingredients harbour high levels of it: Soy sauce,42 hydrolysed vegetable protein, sodium caseinate, textured protein, autolyzed yeast, yeast extract, natural flavours #621, gelatin, seasonings, carrageenan, just to name a few. If your food is processed, fermented or has food additives in it there is a high likelihood it contains hidden MSG. Pickles with their vinegar and high nitrates increase your risk of dementia.43

Certain food combinations challenge our health and increase the risk for brain deterioration, for example large varieties at any one meal, especially if they contain a mixture of fruits and vegetables at the same sitting. Complex meals with a high variety of food items or dishes confuse your stomach, slow your digestion, and increase brain inflammation, laying the ground work for dementia.44

Avoid caffeine brain!45 Caffeine decreases mental performance.46,47 It really does not improve alertness, but merely returns the addict to baseline.48 What’s more, it disturbs sleep49 and reduces the Alzheimer’s preventing50 hormone melatonin.51

Smoking is not helpful either, it increases your risk of Alzheimer’s by 60%.52

Drinking a glass of red wine a day for your heart?53 Alcohol causes loss of important neurons and increases Alzheimer’s changes in your brain. In Alzheimer disease, the tau protein is aggregated into bundles of filaments referred to as neurofibrillary tangles. Drinking alcohol is associated with increased tau neurofibrillary tangle accumulation.54

Striking closer to home, both hypersexuality55 and masturbation56 increase your risk of Alzheimer’s by depleting of the dementia preventing mineral zinc.57,58

Neurotoxic herbicides, like glyphosate (brand name RoundUp and others), cause oxidative damage to your brain and increase the likelihood of dementia.59,60,61 Glyphosate can certainly be in any agricultural products, but especially be careful of grains, beans, cotton, contaminated air, fruits and vegetables, and your drinking water. Danger of Alzheimer’s is not limited to herbicides, exposure to pesticide residues increase your risk of dementia by 34%.62 Pesticides are commonly found in commercially grown foods, drinking water, contaminated air and dust.


Chemicals toxic to your brain, like formaldehyde, are often found in household building materials, synthetic clothing, and many medications.63,64

Arsenic in your diet compromises your brain’s function and significantly increases your risk of Alzheimer’s.65 Sources of exposure to arsenic include: chicken,66 eggs,67 food grown in chicken litter,68 fish, sea food,69 yogurt,70 bottled water,71 some rice, sugars and sweeteners.72

Due to media coverage, popular opinion, and the press, it is no secret that aluminium plays a significant role in the development of Alzheimer’s dementia. Indeed, laboratory animals fed aluminium, accumulate aluminium in their brains and experience cognitive deterioration.73 Aluminium can cause accumulation of Alzheimer’s neurofibrillary tangles in your brain.74 Sources of aluminium for humans include: cheese, baking powder: pancake and waffle mixes, biscuits, cakes, cookware, tea, drinking water, vaccinations, geoengineering,75 antacids, chocolate, non- dairy creamers, salt, and toothpaste.76,77

As if aluminium were not bad enough by its self, combine it with fluoride and the result is even more dramatic.78 Indeed, fluoride and aluminium are also used to produce Alzheimer’s in laboratory animals.79 Common sources of fluoride include: tea,80 toothpaste, drinking water,81 salt,82 non-stick cookware,83 pesticides, fertilizers84 and medications.85

Heavy metals can also play a role in Alzheimer’s. Mercury and bromide levels are higher in Alzheimer’s patients.86 Mercury can be from: processed foods,87 dental fillings,88 vaccines,89,90 fish,91 medications,92 mushrooms93 and Corn sweeteners.94 Bromine can be from: fire retardants,95 food preservatives, fumigants,96 pesticides,97 fish,98 dough conditioners in bread,99 plastics,100 Soft drinks,101 vegetable oils, and swimming pool treatments.102 One of the reasons bromine and fluoride increase the likelihood of getting Alzhiemer’s is their competitiveness with iodine. Iodine deficiency plays a role in Alzheimer's and Parkinson's diseases.103 Supplementing with Iodine can have its benefits if you are deficient.

Many of the drug medications people take increase the risk of dementia. For example, statins (cholesterol lowering medications), diuretics (used for high blood pressure and edema),104 proton pump inhibitors (drugs for heartburn and reflux disease),105 and anti-inflammatory drugs (pain relievers for arthritis and other pains),106 anticholinergic drugs (antipsychotics for mental disorders),107 etc., all significantly increase the risk for dementia or make its symptoms worse. Being put to sleep for surgery can cause brain fog and increase your risk of dementia.108

I think I have shared most of the bad news first, and now I will share some good news. There is hope! Your brain runs and thrives on good nutrients. To protect your brain from deterioration, you need to eat more nutrient dense fresh fruits and vegetables.109 It is simple, just increase the percentage and variety of fruits and vegetables in your diet.110 The increased consumption of fruit and vegetables is associated with a reduced risk of cognitive impairment and dementia.111 Variety more than total quantity of fruits and vegetables helps protect cognitive function.112

“But I don’t like eating salads and veggies,” you may be thinking, “can I just juice them or blend them into smoothies and just quickly drink them?” With such glamorous article titles as, “Juice your way to fabulous health?” appearing in print, you may be thinking that this is the way to get your best nutrition, but not so according to scientific research. People who drink juice every day have lower brain volumes and poorer memories.113


And why are fresh fruits and vegetables so helpful? It is because they are richer in vitamins. Vitamins give life to your brain, and you can just eat them in your food. Vitamin A, protects against dementia and can be obtained from sweet potato, carrots, kale, spinach.114 B vitamins, protect against Alzheimer’s disease and are found in grains, seeds, beans, nuts, greens. The earliest and perhaps best example of an interaction between nutrition and dementia is related to thiamine (vitamin B1). Throughout the last century, research showed that thiamine deficiency is associated with neurological problems, including cognitive deficits and encephalopathy.115 Evidence supports the role for riboflavin (vitamin B2) in slowing the progression of cognitive decline.116 Higher intake of B vitamins: niacin (B3), pyridoxine (B6), folate (B9), and cobalamin (B12) throughout young adulthood was associated with better cognitive function in midlife.117 Vitamin C, lowers the risk of dementia and can be obtained from capsicum (bell peppers), kiwi, red cabbage, and citrus.118 Vitamin D deficiency doubles the risk of Alzheimer’s. The best source is actually not from the diet but from sunlight. If your serum 25(OH)D level is below 10 ng/mL you are more than twice as likely to develop Alzheimer disease than if it is greater than 20 ng/mL.119 Vitamin E helps maintain better brain nutrition. Good sources include sunflower seeds, almonds, and flax.120 Vitamin K deficiency is associated with Alzheimer’s. Best foods sources of Vitamin K are dark green leafy vegetables, onions, and peppers.121 If you are on a plant-based diet your intake of antioxidants is significantly greater than that of meat eaters. For example, your intake of vitamin C is 305% higher than the recommended, vitamin A intake is 247% higher, and vitamin E 313% higher.122 There are a lot of delicious foods in the plant kingdom high in nutrients designed to be of benefit to your brain.


Vegetables are highly nutritious. Cruciferous and green leafy vegetables can slow cognitive decline and lower your risk of dementia as you get older.123 Cruciferous vegetable intake has been demonstrated to slow the progress of cognitive decline.124 Consumption of as little as one serving per day of green leafy vegetables can slow cognitive decline as you age. According to one study, daily green leafy veggie consumption keeps your brain an equivalent of 11 years younger.125

Fruit is highly nutrient dense. Compared to eating less than one piece of fruit per day, consuming 2 to 3 pieces daily can reduce Alzheimer’s mortality by 40% and eating more than 3 pieces per day have been shown to reduce it by 60%.126

Berries are particularly nutrient dense and high in antioxidants making them very desirable for both reversing and preventing dementia.127 Blueberries help counteract the brain damaging effects of a high fat diet.128 Cranberries can prevent the toxic effects of amyloid in Alzheimer's disease.129 Red raspberries exhibit health-promoting properties which have critical metabolic, oxidative, and anti-inflammatory links to preventing Alzheimer disease.130 Mulberries can be a natural cognitive enhancer and neuroprotectant.131 Strawberries (best eaten organic to avoid chemicles) have been shown to reverse age-related losses in motor and cognitive performance.132 Blackberries improve age related deterioration of motor and cognitive performance.133 Grapes help maintain brain metabolism and cognitive function in patients with mild decline in thinking ablity.134 Tomatoes, with their lycopene, help to protect against Alzheimer’s induced cognitive dysfunction.135 Higher serum levels of lycopene are associated with a lower risk of Alzheimer’s mortality in adults.136 Eat all the berries you can get your hands on!


Other fruits are also helpful. Pomegranate consumption has been shown to significantly improve memory and brain function.137 Apples have been shown to return brain function to younger levels.138 Plums have been shown to improved working memory, mitigating against age-related declines in brain function.139 Citrus has been shown to be a valuable weapon against Alzheimer’s dementia.140 Peppers (capsicum, which is a fruit not a vegetable) have been shown to inhibit the formation of Alzheimer’s amyloid in the brain.141 Many fruits are helpful event though they have not all have been specifically studied; fruit of any kind can be beneficial, get as much as you can.


Olives are high in antioxidants that prevent neurodegenerative diseases and are associated with reduced risk of mild cognitive impairment and Alzheimer's disease.142,143 Olives have been shown to prevent neurofibrillary tangles from tau fibrillization.144

Whole grains, in distinction to refined processed grains, have antioxidant activity and minerals which protect your brain against Alzheimer’s.145

Higher consumption of whole legumes (beans) decreases cognitive decline as you get older.146

Raw nut consumption helps dementia because it reduces blood pressure, improves blood sugar regulation, improves vascular function, reduces inflammation, and also improves cognitive performance.147 Eating nuts can delay cognitive decline in old age.148 Walnuts are of particular interest because they have been demonstrated to improve scores on brain function tests.149 Polyphenolic compounds found in walnuts not only reduce the oxidant and inflammatory load on brain cells but also improve intraneuronal signaling, increase neurogenesis, and help the brain deal with neurofibrillary tangles.150 Hazelnuts improve memory, reduce anxiety-related behavior, and have an ameliorating effect on the toxic nature of amyloid.151 Brazil nuts with their relatively high selenium content help with cognitive impairment.152,153 Almonds, along with some of the other nuts, provide macronutrients, micronutrients, and phytochemicals that affect several pathways in Alzheimer’s pathogenesis such as amyloid and tau protein dysfunction, and oxidative stress; additionally they lower cholesterol, reduce inflammation, and promote neurogenesis.154

Seeds, like nuts, have many nutrients which can positively impact brain performance. Flax seed (linseed) has been shown to improve mental performance.155 Sesame seed protects against Alzheimer’s amyloid toxicity.156

Do you have some areas of food choices where you could make more positive selections to better prevent and lower your risk of Alzheimer’s?

Did you know that herbs can help you fight Alzheimer’s disease? “He causeth the grass to grow for the cattle, and herb for the service of man: that he may bring forth food out of the earth;”157 Red clover: (Trifolium pratense) protects neurons from glutamate (MSG) damage.158 Gotu Kola: nullifies aluminium toxicity159 and decreases amyloid levels.160 Panax ginseng: significantly improves frontal lobe function in Alzheimer’s.161 Ginkgo biloba: helps mild to moderate Alzheimer’s dementia.162 Huperzia serrata: produces cognitive enhancement and improves memory.163 Salvia officinalis: (Sage) improves cognitive function in Alzheimer's.164 Horsetail: contains silica which reduces dementia and Alzheimer’s.165 So pick a few of these herbs and make yourself a nice cup of tea.


Essential oil from Japanese Hinoki Cypress trees can prevent neuronal cell death in Alzheimer’s.166


Have you drunk your water today? Good hydration improves your memory and intelligence reducing your risk of Dementia.167 Start the day off with a litre (quart) of water. Men need 3.7 litres (quarts) a day and women need 2.7 litres (quarts) a day.168 Hydrotherapy can also prevent and treat dementia.169 A cool morning sponge bath stimulates your nerves. Hot and cold showers are invigorating to your brain’s circulation. A hot foot bath can improve mental status. Hot and cold treatments to the head can improve your brain blood supply and oxygenation. Sauna bathing can reduce your risk of Alzheimer’s.170

The risk of dementia increases with either too little or with too much sleep. Regularity in bedtime improves your memory. Best time for sleep: 9pm to 5am. Sleeping pills increase your risk of dementia 66%.171 Especially deleterious is the consumption of a large evening meal. It compromises sleep which increase Alzheimer’s.172,173 It also increases the bodies core temperature at night which also increases Alzheimer’s.174,175 If any food is eaten at all in the evening, the meal should be at the same time every day, be at least 3 hours before bedtime, be at least 5 hours after lunch and should consist only of fruit and possibly a small serving of some whole grain product. Avoid vegetables, animal products, fats and hard to digest foods in the evening. Reading late in the evening or watching TV also disrupts sleep increasing the risk of Alzheimer’s.176 Good sleep is associated with good melatonin levels. Alzheimer’s risk rises when your melatonin levels fall. Melatonin levels fall with late bedtimes, after 9:30pm, artificial lighting after sundown, blue/white light in the evening (like from TV, computers or mobile phones, night lights, illuminated clocks), irregular eating and sleeping schedules, and shift work.177,178



With the electronic age and media entertainment also comes the hazard of electromagnetic fields. Electromagnetic Fields (EMF) increase your risk of Alzheimer’s.181 Electromagnetic fields can come from mobile phones and cordless phones (especially DECT), Wi-Fi and computers, smart meters, radio towers, electronic devices, and high power lines.182,183

There is some entertainment that can be beneficial. Listening to, singing,184 or playing185 good music can improve your memory, mood and thinking. Putting things you need to memorize to music is also an effective way to improve memory in Alzheimer’s.186

Music is often associated with reflection or meditation. Meditation relieves stress, increases brain blood flow and your brain volume, and it reduces your risk of cognitive decline.187,188 “O how love I thy law! it is my meditation all the day.”189

Regular physical activity sharpens the brain, improves memory and thinking skills, and helps prevent Alzheimer’s.190 In fact, exercise can be more effective than diet control in preventing amyloid deposition and memory deficits.191 Moderate intensity aerobic exercise can improve cognitive function in patients with mild Alzheimer's disease. Those who are more active can improve their brain function by 32-39%.192 Best exercise times are before breakfast and after each meal. The best exercise you can engage in is walking. Walking improves brain function,193 increases memory,194 and reduces risk of dementia.195 The best place to exercise is out in nature, away from the busyness of the city with its noise and pollution. Pure air is beneficial while air pollution increases Alzheimer’s brain changes.196 Improved ventilation with outdoor air improves mental performance.197,198 A healthy life style, with daily outdoor activity, reduces your risk of dementia.199 Physical exercise in a natural outdoor environment lowers your risk of Alzheimer’s by its positive effects on blood pressure and inflammation.200,201,202 The natural environment also includes sunshine. Countries with lower average sunlight have higher Alzheimer’s death rates.203 Morning sunlight helps depression. Afternoon sunlight increases vitamin D.204


Combined physical and mental exercise improves your mental performance more compared to physical exercise alone.205,206


Having a purpose and doing things purposefully with your whole heart protects your neurons.207 In fact, a person with purpose is 2.4 times more likely to remain free of Alzheimer’s.208 Daydreaming has negative effects increasing your risk of Alzheimer’s. “Whatsoever thy hand findeth to do, do it with thy might; for there is no work, nor device, nor knowledge, nor wisdom, in the grave, whither thou goest.”209

The name of the game is purposeful physical activity that engages the intellect as well as your muscles. What activities are available to you that could stimulate both your brain and your body?

Have you heard it said, “use it or lose it?” This is definitely true of your brain and risk of Alzheimer’s. If you engage in more active thinking over your lifetime, your chances of having amyloid deposit in your brain are greatly diminished.210 Do things that keep your brain active: keep your own accounts, form your own opinions, make long term plans, learn new skills and improve old ones, take up a new hobby. Keep learning your whole life: it prevents dementia.211,212 Learning stimulates growth of brain networks which bypass damaged areas in your brain.213 Maintaining a high level of mental activity reduces your risk of dementia by 66%.214 Stimulating mental activities might include: reading, discussing, studying, word games, etc. Bible Study is the best mind builder. It is good to fill your leisure time with mind engaging meaningful activities.215 An idle mind is a brain in decline.

Independent thinking and acting maintains better brain function.216 Relying on others is nice, but as much as possible, do all your own thinking, planning, and analyzing.

Memory exercises pay off in helping to maintain and revitalize your memory.217,218 Help your memory by use of object lessons, blackboards, maps, figures, symbols, mnemonics, and pictures.

What strategies have you formulated to stimulate and maintain your memory abilities as you get older?

A joyful heart is good medicine and a positive attitude predicts fewer memory problems.219 Happiness improves your memory.220 As your happiness fluctuates from day to day so does your memory.221 “A merry heart doeth good like a medicine: but a broken spirit drieth the bones.”222

Psychological stress predicts the progression to dementia.223 Psychological distress and depression, anxiety and apathy can be present in mild cognitive impairment and can predict progression to dementia. Chronic stress is a risk factor for Alzheimer’s.224 If you are a person who is prone to stress, then you have a greater chance of coming down with Alzheimer’s.225 Guilt brings the ultimate stress. Depression,226 anxiety,227 dread, loneliness,228 and poor self- esteem229 can all give you Alzheimer’s. Take life one day at a time.

Stress is about your emotions. What we are talking about here is having good emotional health to escape Alzheimer’s. The fruits of the Spirit are a good list of positive emotions worth cultivating in prevention of dementia. “But the fruit of the Spirit is love, joy, peace, patience, kindness, goodness, faithfulness, gentleness and self-control.”230

Christianity has been shown to reduce your risk of Alzheimer’s by 50%.231 Regular church attendance reduces the incidence of dementia.232 Your brain benefits from the personal and group Bible study, prayer, meditation, and memorisation available in the setting of a church. Christianity offers stress reduction, mental quietude and acquiescence—complete confidence in God to work out all difficulties satisfactorily. Bible study, comparing text with text, is a real workout for your brain’s association cortex. And true Christianity leads you to live to help others. Selflessness in volunteering has been shown to preserve your intellectual capacity.233 Volunteers had 78% less intellectual decline over a one-year period compared to non- volunteers.

Make friends! Having 5-6 close friends decreases your risk of cognitive decline by 250%.234 People with more friends were found to have better cognitive function and lower rates of Alzheimer’s.235

What we are talking about here is social health as a benefit to long term cognitive functioning. One way to improve your social health is to practice the one another texts. Love one another (John 13:34,35). Accept one another (Romans 15:7). Pray for one another (James 5:17). Honor one another (Romans 12:10). Encourage one another (1Theselonians 5:11). Carry one another’s burdens (Galatians 6:2). Serve one another (Galatians 5:13). These all have practical potential to increase brain activity and stave off dementia.

Given the high impact of stress and negative emotions on brain health, I want to ask an important question. Do you have inner peace?

“In the heart of Christ, where reigned perfect harmony with God, there was perfect peace. He was never elated by applause, nor dejected by censure or disappointment. Amid the greatest opposition and the most cruel treatment, He was still of good courage. But many who profess to be His followers have an anxious, troubled heart, because they are afraid to trust themselves with God. They do not make a complete surrender to Him; for they shrink from the consequences that such a surrender may involve. Unless they do make this surrender, they cannot find peace.”


“It is the love of self that brings unrest. When we are born from above, the same mind will be in us that was in Jesus, the mind that led Him to humble Himself that we might be saved. Then we shall not be seeking the highest place. We shall desire to sit at the feet of Jesus, and learn of Him. We shall understand that the value of our work does not consist in making a show and noise in the world, and in being active and zealous in our own strength. The value of our work is in proportion to the impartation of the Holy Spirit. Trust in God brings holier qualities of mind, so that in patience we may possess our souls.”


“The yoke is placed upon the oxen to aid them in drawing the load, to lighten the burden. So with the yoke of Christ. When our will is swallowed up in the will of God, and we use His gifts to bless others, we shall find life’s burden light. He who walks in the way of God’s commandments is walking in company with Christ, and in His love the heart is at rest. When Moses prayed, ‘Show me now Thy way, that I may know Thee,’ the Lord answered him, ‘My presence shall go with thee, and I will give thee rest.’ And through the prophets the message was given, ‘Thus saith the Lord, Stand ye in the ways, and see, and ask for the old paths, where is the good way, and walk therein, and ye shall find rest for your souls.’ Exodus 33:13, 14; Jeremiah 6:16. And He says, ‘O that thou hadst hearkened to My commandments! then had thy peace been as a river, and thy righteousness as the waves of the sea.’ Isaiah 48:18.”

“Those who take Christ at His word, and surrender their souls to His keeping, their lives to His ordering, will find peace and quietude. Nothing of the world can make them sad when Jesus makes them glad by His presence. In perfect acquiescence there is perfect rest. The Lord says, ‘Thou wilt keep him in perfect peace, whose mind is stayed on Thee: because he trusteth in Thee.’ Isaiah 26:3. Our lives may seem a tangle; but as we commit ourselves to the wise Master Worker, He will bring out the pattern of life and character that will be to His own glory. And that character which expresses the glory—character—of Christ will be received into the Paradise of God. A renovated race shall walk with Him in white, for they are worthy.”


“As through Jesus we enter into rest, heaven begins here. We respond to His invitation, Come, learn of Me, and in thus coming we begin the life eternal. Heaven is a ceaseless approaching to God through Christ. The longer we are in the heaven of bliss, the more and still more of glory will be opened to us; and the more we know of God, the more intense will be our happiness. As we walk with Jesus in this life, we may be filled with His love, satisfied with His presence. All that human nature can bear, we may receive here. But what is this compared with the hereafter? There ‘are they before the throne of God, and serve Him day and night in His temple: and He that sitteth on the throne shall dwell among them. They shall hunger no more, neither thirst any more; neither shall the sun light on them, nor any heat. For the Lamb which is in the midst of the throne shall feed them, and shall lead them unto living fountains of waters: and God shall wipe away all tears from their eyes.’ Revelation 7:15-17.”236


Summary

Alzheimer’s, dementia, and memory failure are increasing alarmingly and are at an all-time high. Why? Your brain is under attack from poor lifestyle habits, environmental insults, and psychological stress. Your solution is to eat well, live well, and think well.

Recommendations:

  • Eat plenty of fresh fruits and vegetables, whole grains, legumes, nuts and seeds, but don’t overeat.

  • Limit or avoid animal products, fatty foods (including oils), fermented foods, processed foods and chemicalized foods.

  • Eat only at scheduled mealtimes and eat very little if anything in the evening.

  • Take time daily for vigorous exercise in the great outdoors in the fresh air, sunshine and in as natural an environment as possible. Useful purposeful labour is the very best.

  • Drink plenty of fresh pure water.

  • Avoid heavy metals, chemicals, pesticides, MSG, and herbicides.

  • Keep your mind active and challenged every day.

  • Make friends and build social networks.

  • Take steps to manage stress effectively.

  • Take advantage of the help God can give you in living to the fullest free from stress and worry.

References

1 https://www.dementia.org.au/statistics
2 Cantegreil-Kallen I, Pin S. Fear of Alzheimer's disease in the French population: impact of age and proximity to the disease. Int Psychogeriatr. 2012 Jan;24(1):108- 16.
3 https://www.dementia.org.au/about-dementia/what-is-dementia
4 https://www.aihw.gov.au/reports/life-expectancy-death/deaths-in- australia/contents/leading-causes-of-death
5 Bloom GS Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 2014 Apr;71(4):505-8.
6 https://www.alz.org/alzheimers-dementia/stages
7 https://www.cdc.gov/aging/aginginfo/pdfs/ALZ-module2-ALZ-other-dementias- The-Basics.pdf
8 https://www.alz.org/national/documents/checklist_10signs.pdf
9 Toda N, Ayajiki K, Okamura T. Obesity-induced cerebral hypoperfusion derived from endothelial dysfunction: one of the risk factors for Alzheimer's disease. Curr Alzheimer Res. 2014;11(8):733-44.
10 Ghanim H, Monte SV, Sia CL, Abuaysheh S, Green K, Caruana JA, Dandona P.Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery. J Clin Endocrinol Metab. 2012 Jul;97(7):E1197-201.
11 Pasinetti GM, Zhao Z, Qin W, Ho L, Shrishailam Y, Macgrogan D, Ressmann W, Humala N, Liu X, Romero C, Stetka B, Chen L, Ksiezak-Reding H, Wang J. Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications. Interdiscip Top Gerontol. 2007;35:159-75.
12 Kagawa Y. Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians. Prev Med. 1978 Jun;7(2):205-17.
13 Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2007 Apr;26(1):212-20. Epub 2007 Jan 13.
14 Aksenova MV, Aksenov MY, Carney JM, Butterfield DA. Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction.Mech Ageing Dev. 1998 Jan 30;100(2):157-68.
15 Mattson MP, Duan W, Guo Z. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.J Neurochem. 2003 Feb;84(3):417-31.
16 Mattson MP, Duan W, Guo Z. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem. 2003 Feb;84(3):417-31.
17 Loh DH, Jami SA, Flores RE, Truong D, Ghiani CA, O'Dell TJ, Colwell CS. Misaligned feeding impairs memories. Elife. 2015 Dec 10;4. pii: e09460.
18 Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry. 2010 Mar 15;67(6):505-12.
19 Ryan D. Obesity in women: a life cycle of medical risk.Int J Obes (Lond). 2007 Nov;31 Suppl 2:S3-7; discussion S31-2.
20 Ozawa M, Shipley M, Kivimaki M, Singh-Manoux A , Brunner EJ. Dietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study. Clin Nutr. 2017 Apr;36(2):506-512.
21 Grant WB. Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries. J Alzheimers Dis. 2014;38(3):611-20.
22 Thomas MH, Paris C, Magnien M, Colin J, Pelleïeux S, Coste F, Escanyé MC, Pillot T, Olivier JL. Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance. Alzheimers Res Ther. 2017 Aug 29;9(1):69.
23 Crichton GE, Murphy KJ, Bryan J. Dairy intake and cognitive health in middle- aged South Australians.Asia Pac J Clin Nutr. 2010;19(2):161-71.
24 Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Dietary fat intake and 6-year cognitive change in an older biracial community population. Neurology. 2004 May 11;62(9):1573-9.
25 Berrino F. Western diet and Alzheimer's disease. Epidemiol Prev. 2002 May- Jun;26(3):107-15.
26 Linardaki ZI, Lamari FN, Margarity M. Saffron (Crocus sativus L.) Tea Intake Prevents Learning/Memory Defects and Neurobiochemical Alterations Induced by Aflatoxin B1 Exposure in Adult Mice.Neurochem Res. 2017 Oct;42(10):2743- 2754.
27 Power SE, O'Connor EM, Ross RP, Stanton C, O'Toole PW, Fitzgerald GF, Jeffery IB. Dietary glycaemic load associated with cognitive performance in elderly subjects.Eur J Nutr. 2015 Jun;54(4):557-68.

28 Taylor MK, Sullivan DK, Swerdlow RH, Vidoni ED, Morris JK, Mahnken JD, Burns JM. A high-glycemic diet is associated with cerebral amyloid burden in cognitively normal older adults. Am J Clin Nutr. 2017 Dec;106(6):1463-1470.
29 Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimers Dement. 2017 Sep;13(9):955-964.

30 Vercambre MN, Boutron-Ruault MC, Ritchie K, Clavel-Chapelon F, Berr C. Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women. Br J Nutr. 2009 Aug;102(3):419-27.

31 Larry Sparks D. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain. J Mol Neurosci. 2004;24(1):97-104. 32 Broxmeyer L. Thinking the unthinkable: Alzheimer's, Creutzfeldt-Jakob and Mad Cow disease: the age-related reemergence of virulent, foodborne, bovine

6

tuberculosis or losing your mind for the sake of a shake or burger. Med Hypotheses. 2005;64(4):699-705.
33 Athari Nik Azm S, Djazayeri A, Safa M, Azami K, Ahmadvand B, Sabbaghziarani F, Sharifzadeh M, Vafa M.Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1-42) injected rats.,Appl Physiol Nutr Metab. 2018 Jul;43(7):718-726.

34 Noble EE, Hsu TM, Kanoski SE. Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment. Front Behav Neurosci. 2017 Jan 30;11:9.
35 Campbell AW, rasher JD, Madison RA, Vojdani A, Gray MR, Johnson A. Neural autoantibodies and neurophysiologic abnormalities in patients exposed to molds in water-damaged buildings. Arch Environ Health (2003) 58(8):464–74.

36 Morris G, Berk M, Walder K, Maes M. The putative role of viruses, bacteria, and chronic fungal biotoxin exposure in the genesis of intractable fatigue accompanied by cognitive and physical disability. Mol Neurobiol (2016) 53(4):2550–71.
37 Gordon WA, Cantor JB, Johanning E, Charatz HJ, Ashman TA, Breeze JL, et al. Cognitive impairment associated with toxigenic fungal exposure: a replication and extension of previous findings. Appl Neuropsychol (2004) 11(2):65–74.

38 ChenR;MaF;LiPW;ZhangW;DingXX;ZhangQ;LiM;WangYR;XuBC. Effect of ozone on aflatoxins detoxification and nutritional quality of peanuts. Food Chem. 2014; 146:284-8.
39 Madhavadas S, Kutty BM, Subramanian S. Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity.Indian J Biochem Biophys. 2014 Aug;51(4):257-62.

40 Dief AE, Kamha ES, Baraka AM, Elshorbagy AK. Monosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: a potential role for cyclic AMP protein kinase. Neurotoxicology. 2014 May;42:76-82.
41 Esclaire F, Lesort M, Blanchard C, Hugon J. Glutamate toxicity enhances tau gene expression in neuronal cultures. J Neurosci Res. 1997 Aug 1;49(3):309-18. 42 Ito K, Koyama Y, Hanya Y. Identification of the glutaminase genes of Aspergillus sojae involved in glutamate production during soy sauce fermentation. Biosci Biotechnol Biochem. 2013;77(9):1832-40.

43 Tripathi M, Vibha D, Gupta P, Bhatia R, Srivastava MV, Vivekanandhan S, Bhushan Singh M, Prasad K, Dergalust S, Mendez MF.Risk factors of dementia in North India: a case-control study. Aging Ment Health. 2012;16(2):228-35.
44 Ferguson AC. Food allergy.Prog Food Nutr Sci. 1984;8(1-2):77-107.

45 Gilliland K, Andress D. Ad lib caffeine consumption, symptoms of caffeinism, and academic performance. Am J Psychiatry. 1981 Apr;138(4):512-4.
46 Champlin SE, Pasch KE, Perry CL. Is the Consumption of Energy Drinks Associated With Academic Achievement Among College Students? J Prim Prev. 2016 Aug;37(4):345-59.

47 Lesk VE, Honey TE, de Jager CA. The effect of recent consumption of caffeine- containing foodstuffs on neuropsychological tests in the elderly. Dement Geriatr Cogn Disord. 2009;27(4):322-8.
48 Rogers PJ, Hohoff C, Heatherley SV, Mullings EL, Maxfield PJ, Evershed RP, Deckert J, Nutt DJ. Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. Neuropsychopharmacology. 2010 Aug;35(9):1973-83.

49 Shilo L, Sabbah H, Hadari R, Kovatz S, Weinberg U, Dolev S, Dagan Y, Shenkman L. The effects of coffee consumption on sleep and melatonin secretion. Sleep Med. 2002 May;3(3):271-3.
50 Lin L, Huang QX, Yang SS, Chu J, Wang JZ, Tian Q. Melatonin in Alzheimer's disease. Int J Mol Sci. 2013 Jul 12;14(7):14575-93.
51 Dragicevic N, Delic V, Cao C, Copes N, Lin X, Mamcarz M, Wang L, Arendash GW, Bradshaw PC. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells. Neuropharmacology. 2012 Dec;63(8):1368-79.
52 Peters R, Poulter R, Warner J, Beckett N, Burch L, Bulpitt C. Smoking, dementia and cognitive decline in the elderly, a systematic review. BMC Geriatr. 2008 Dec 23;8:36.
53 https://www.theguardian.com/science/sifting-the-evidence/2014/apr/22/drinking- wine-health-evidence-alcohol-units
54 Gendron TF, McCartney S, Causevic E, Ko LW, Yen SH. Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. Neurosci Lett. 2008 Oct 3;443(2):67-71.
55 Rogers C, Bernstein G, Nakamura R, Endahl G, Bhoopat T. Vaginal fluid zinc concentration as a marker for intercourse. J Forensic Sci. 1988 Jan;33(1):77-83.
56 Purvis K, Magnus O, Mørkås L, Abyholm T, Rui H. Ejaculate composition after masturbation and coitus in the human male. Int J Androl. 1986 Dec;9(6):401-6.
57 Szewczyk B. Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci. 2013 Jul 19;5:33.
58 Gromova OA, Torshin IY, Pronin AV, Kilchevsky MA. Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(7):112-119.
59 Sarkar S, Das R. PVP capped silver nanocubes assisted removal of glyphosate from water-A photoluminescence study. J Hazard Mater. 2017 Oct 5;339:54-62.
60 Ait Bali Y, Ba-Mhamed S, Bennis M. Behavioral and Immunohistochemical Study of the Effects of Subchronic and Chronic Exposure to Glyphosate in Mice. Front Behav Neurosci. 2017 Aug 8;11:146.
61 Cattani D, de Liz Oliveira Cavalli VL, Heinz Rieg CE, Domingues JT, Dal-Cim T, Tasca CI, Mena Barreto Silva FR, Zamoner A. Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity. Toxicology. 2014 Jun 5;320:34-45.
62 Yan D, Zhang Y, Liu L, Yan H. Pesticide exposure and risk of Alzheimer's disease: a systematic review and meta-analysis. Sci Rep. 2016 Sep 1;6:32222.

63 Liu X, Zhang Y, Luo C, Kang J, Li J, Wang K, Ma P, Yang X. At seeming safe concentrations, synergistic effects of PM2.5 and formaldehyde co-exposure induces Alzheimer-like changes in mouse brain. Oncotarget. 2017 Oct 6;8(58):98567-98579.

64 Tulpule K, Dringen R. Formaldehyde in brain: an overlooked player in neurodegeneration? J Neurochem. 2013 Oct;127(1):7-21.
65 O'Bryant SE, Edwards M, Menon CV, Gong G, Barber R. Long-term low-level arsenic exposure is associated with poorer neuropsychological functioning: a Project FRONTIER study. Int J Environ Res Public Health. 2011 Mar;8(3):861-74. 66 Nigra AE, Nachman KE, Love DC, Grau-Perez M, Navas-Acien A. Poultry Consumption and Arsenic Exposure in the U.S. Population. Environ Health Perspect. 2017 Mar;125(3):370-377.
67 Holcman A, Stibilj V. Arsenic residues in eggs from laying hens fed with a diet containing arsenic (III) oxide. Arch Environ Contam Toxicol. 1997 May;32(4):407-10.
68 Gupta SK, Le XC, Kachanosky G, Zuidhof MJ, Siddique T. Transfer of arsenic from poultry feed to poultry litter: A mass balance study. Sci Total Environ. 2018 Jul 15;630:302-307.
69 Fort M, Grimalt JO, Casas M, Sunyer J. Food sources of arsenic in pregnant Mediterranean women with high urine concentrations of this metalloid. Environ Sci Pollut Res Int. 2014 Oct;21(20):11689-98.
70 Osorio-Yáñez C, Gelaye B, Enquobahrie DA, Qiu C, Williams MA. Dietary intake and urinary metals among pregnant women in the Pacific Northwest. Environ Pollut. 2018 May;236:680-688.
71 Sullivan MJ, Leavey S. Heavy metals in bottled natural spring water. J Environ Health. 2011 Jun;73(10):8-13.
72 deCastro BR, Caldwell KL, Jones RL, Blount BC, Pan Y, Ward C, Mortensen ME. Dietary sources of methylated arsenic species in urine of the United States population, NHANES 2003-2010. PLoS One. 2014 Sep 24;9(9):e108098.
73 Walton JR. An aluminum-based rat model for Alzheimer's disease exhibits oxidative damage, inhibition of PP2A activity, hyperphosphorylated tau, and granulovacuolar degeneration. J Inorg Biochem. 2007 Sep;101(9):1275-84.
74 Yumoto S, Kakimi S, Ohsaki A, Ishikawa A. Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer's disease. J Inorg Biochem. 2009 Nov;103(11):1579-84.
75 Herndon JM. Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. Front Public Health. 2016 Jun 30;4:139.
76 Saiyed SM, Yokel RA. Aluminium content of some foods and food products in the USA, with aluminium food additives. Food Addit Contam. 2005 Mar;22(3):234-44.
77 Rajwanshi P, Singh V, Gupta MK, Kumari V, Shrivastav R, Ramanamurthy M, Dass S. Studies on aluminium leaching from cookware in tea and coffee and estimation of aluminium content in toothpaste, baking powder and paan masala. Sci Total Environ. 1997 Jan 30;193(3):243-9.
78 Allain P, Gauchard F, Krari N. Enhancement of aluminum digestive absorption by fluoride in rats. Res Commun Mol Pathol Pharmacol. 1996 Feb;91(2):225-31.
79 Hussien HM, Abd-Elmegied A, Ghareeb DA, Hafez HS, Ahmed HEA, El- Moneam NA. Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer's-like disease in rats. Food Chem Toxicol. 2018 Jan;111:432-444.
80 Gao HJ, Zhao Q, Zhang XC, Wan XC, Mao JD. Localization of fluoride and aluminum in subcellular fractions of tea leaves and roots. J Agric Food Chem. 2014 Mar 12;62(10):2313-9.
81 Peckham S, Awofeso N. Water fluoridation: a critical review of the physiological effects of ingested fluoride as a public health intervention. ScientificWorldJournal. 2014 Feb 26;2014:293019.
82 Götzfried F. Legal aspects of fluoride in salt, particularly within the EU. Schweiz Monatsschr Zahnmed. 2006;116(4):371-5.
83 Full CA, Parkins FM. Effect of cooking vessel composition on fluoride. J Dent Res. 1975 Jan-Feb;54(1):192.
84 Luo W, Gao X, Zhang X. Geochemical processes controlling the groundwater chemistry and fluoride contamination in the Yuncheng Basin, China-An area with complex hydrogeochemical conditions. PLoS One. 2018 Jul 26;13(7):e0199082.
85 http://www.slweb.org/ftrcfluorinatedpharm.html
86 Wenstrup D, Ehmann WD, Markesbery WR. Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains.Brain Res. 1990 Nov 12;533(1):125-31.
87 Martins C, Vasco E, Paixão E, Alvito P. Total mercury in infant food, occurrence and exposure assessment in Portugal. Food Addit Contam Part B Surveill. 2013;6(3):151-7.
88 Reinhardt JW. Side-effects: mercury contribution to body burden from dental amalgam. Adv Dent Res. 1992 Sep;6:110-3.
89 Chhawchharia R, Puliyel JM. Commentary--Controversies surrounding mercury in vaccines: autism denial as impediment to universal immunisation. Indian J Med Ethics. 2014 Oct-Dec;11(4):218-22.
90 Dórea JG. Low-dose Thimerosal (ethyl-mercury) is still used in infants` vaccines: Should we be concerned with this form of exposure? J Trace Elem Med Biol. 2018 Sep;49:134-139.
91 Gandhi N, Tang RW, Bhavsar SP, Arhonditsis GB. Fish mercury levels appear to be increasing lately: a report from 40 years of monitoring in the province of Ontario, Canada. Environ Sci Technol. 2014 May 20;48(10):5404-14. 92https://www.fda.gov/RegulatoryInformation/LawsEnforcedbyFDA/SignificantA mendmentstotheFDCAct/FDAMA/ucm100218.htm
93 Falandysz J, Drewnowska M. Cooking can decrease mercury contamination of a mushroom meal: Cantharellus cibarius and Amanita fulva. Environ Sci Pollut Res Int. 2017 May;24(15):13352-13357.

7

94 Dufault R, LeBlanc B, Schnoll R, Cornett C, Schweitzer L, Wallinga D, Hightower J, Patrick L, Lukiw WJ. Mercury from chlor-alkali plants: measured concentrations in food product sugar. Environ Health. 2009 Jan 26;8:2.
95 Pazin M, Pereira LC, Dorta DJ. Toxicity of brominated flame retardants, BDE- 47 and BDE-99 stems from impaired mitochondrial bioenergetics. Toxicol Mech Methods. 2015 Jan;25(1):34-41.

96 Bulathsinghala AT, Shaw IC. The toxic chemistry of methyl bromide. Hum Exp Toxicol. 2014 Jan;33(1):81-91.
97 Sosnowska B, Huras B, Bukowska B. Oxidative stress in human erythrocytes treated with bromfenvinphos and its impurities. Pestic Biochem Physiol. 2015 Feb;118:43-9.

98 Fernandes AR, Mortimer D, Rose M, Smith F, Panton S, Garcia-Lopez M. Bromine content and brominated flame retardants in food and animal feed from the UK. Chemosphere. 2016 May;150:472-478.
99 Kurokawa Y, Maekawa A, Takahashi M, Hayashi Y. Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen. Environ Health Perspect. 1990 Jul;87:309-35.
100 Turner A, Filella M. Bromine in plastic consumer products - Evidence for the widespread recycling of electronic waste. Sci Total Environ. 2017 Dec 1;601- .602:374-379
101 Bendig P, Maier L, Vetter W .Brominated vegetable oil in soft drinks - An underrated source of human organobromine intake. Food Chemistry 133(3):678– .682
102 Parinet J, Tabaries S, Coulomb B, Vassalo L, Boudenne JL. Exposure levels to brominated compounds in seawater swimming pools treated with chlorine. Water Res. 2012 Mar 1;46(3):828-36.
103 Foster HD. Disease family trees: the possible roles of iodine in goitre, cretinism, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases and cancers of the thyroid, nervous system and skin. Med Hypotheses. 1987 Nov;24(3):249-63.
104 Longstreth WT Jr, Arnold AM, Beauchamp NJ Jr, Manolio TA, Lefkowitz D, Jungreis C, Hirsch CH, O'Leary DH, Furberg CD. Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke. 2005 Jan;36(1):56-61.
105 Clouston SAP, Shapira O, Kotov R, Lei L, Waszczuk M, Bromet EJ, Luft BJ. Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder. Alzheimers Dement (N Y). 2017 Sep 23;3(4):579- .583
106 Dublin S, Walker RL, Gray SL, Hubbard RA, Anderson ML, Yu O, Montine TJ, Crane PK, Sonnen JA, Larson EB. Use of Analgesics (Opioids and Nonsteroidal Anti-Inflammatory Drugs) and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis. 2017;58(2):435-448.
107 Boccardi V, Baroni M, Paolacci L, Ercolani S, Longo A, Giordano M, Ruggiero C, Mecocci P. Anticholinergic Burden and Functional Status in Older People with Cognitive Impairment: Results from the Regal Project. J Nutr Health Aging. .389-396:)4(21;2017
108 Bianchi SL, Tran T, Liu C, Lin S, Li Y, Keller JM, Eckenhoff RG, Eckenhoff MF. Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging. 2008 Jul;29(7):1002-10.
109 Jiang X, Huang J, Song D, Deng R, Wei J, Zhang Z. Increased Consumption of Fruit and Vegetables Is Related to a Reduced Risk of Cognitive Impairment and Dementia: Meta-Analysis. Front Aging Neurosci. 2017 Feb 7;9:18.
110 Tripathi M, Vibha D, Gupta P, Bhatia R, Srivastava MV, Vivekanandhan S, Bhushan Singh M, Prasad K, Dergalust S, Mendez MF. Risk factors of dementia in North India: a case-control study. Aging Ment Health. 2012;16(2):228-35.
111 Wu L, Sun D, Tan Y. Intake of Fruit and Vegetables and the Incident Risk of Cognitive Disorders: A Systematic Review and Meta-Analysis of Cohort Studies. J Nutr Health Aging. 2017;21(10):1284-1290.
112 Ye X, Bhupathiraju SN, Tucker KL. Variety in fruit and vegetable intake and cognitive function in middle-aged and older Puerto Rican adults. Br J Nutr. 2013 Feb 14;109(3):503-10.
113 Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimers Dement. 2017 Sep;13(9):955-964.
114 Hu P, Bretsky P, Crimmins EM, Guralnik JM, Reuben DB, Seeman TE. Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):616-20.
115 Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J. Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci. 2016 Mar;1367(1):21-30.
116 Moore K, Hughes CF, Ward M, Hoey L, McNulty H. Diet, nutrition and the ageing brain: current evidence and new directions. Proc Nutr Soc. 2018 May;77(2):152-163.
117 Qin B, Xun P, Jacobs DR Jr, Zhu N, Daviglus ML, Reis JP, Steffen LM, Van Horn L, Sidney S, He K. Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2017 Oct;106(4):1032-1040.
118 Cansev M, Turkyilmaz M, Sijben JWC, Sevinc C, Broersen LM, van Wijk N. Synaptic Membrane Synthesis in Rats Depends on Dietary Sufficiency of Vitamin C, Vitamin E, and Selenium: Relevance for Alzheimer's Disease. J Alzheimers Dis. .301-311:)1(59;2017
119 Hoel DG, Berwick M, de Gruijl FR, Holick MF. The risks and benefits of sun exposure 2016. Dermatoendocrinol. 2016 Oct 19;8(1):e1248325.

120 Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer's disease: a meta-analysis. J Alzheimers Dis. .253-8:)2(31;2012
121 Presse N, Shatenstein B, Kergoat MJ, Ferland G. Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. J Am Diet Assoc. 2008 Dec;108(12):2095-9.

122 Rauma AL, Torronen R, Hanninen O, Verhagen H, Mykkanen H. Antioxidant status in long-term adherents to a strict uncooked vegan diet. Am J Clin Nutr. 1995 Dec;62(6):1221-7.
123 Loef M, Walach H. Fruit, vegetables and prevention of cognitive decline or dementia: a systematic review of cohort studies. J Nutr Health Aging. 2012 Jul;16(7):626-30.

124 Nooyens AC, Bueno-de-Mesquita HB, van Boxtel MP, van Gelder BM, Verhagen H, Verschuren WM. Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Br J Nutr. 2011 Sep;106(5):752-61.
125 Morris MC, Wang Y, Barnes LL, Bennett DA, Dawson-Hughes B, Booth SL. Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. Neurology. 2018 Jan 16;90(3):e214-e222.
126 Williams PT. Lower risk of Alzheimer's disease mortality with exercise, statin, and fruit intake. J Alzheimers Dis. 2015;44(4):1121-9.
127 Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M. Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res. 2014 Aug 15;9(16):1557-66.
128 Carey AN, Gomes SM, Shukitt-Hale B. Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem. 2014 May .3972-8:)18(62;7
129 Guo H, Dong YQ, Ye BP. Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease. Chin J Nat Med. 2016 Jun;14(6):427-33.
130 Burton-Freeman BM, Sandhu AK, Edirisinghe I. Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. 2016 Jan 15;7(1):44-65.
131 Kaewkaen P, Tong-Un T, Wattanathorn J, Muchimapura S, Kaewrueng W, Wongcharoenwanakit S. Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia. Evid Based Complement Alternat Med. 2012;2012:263520.
132 Shukitt-Hale B, Bielinski DF, Lau FC, Willis LM, Carey AN, Joseph JA. The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr. 2015 Nov 28;114(10):1542-9.
133 Shukitt-Hale B, Cheng V, Joseph JA. Effects of blackberries on motor and cognitive function in aged rats. Nutr Neurosci. 2009 Jun;12(3):135-40.
134 Lee J, Torosyan N, Silverman DH. Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: A double-blinded placebo controlled pilot study. Exp Gerontol. 2017 Jan;87(Pt A):121-128.
135 Prakash A, Kumar A. Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease. Eur J Pharmacol. 2014 Oct 15;741:104-11.
136 Min JY, Min KB. Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults. Dement Geriatr Cogn Disord. .246-56:)3-4(37;2014
137 Bookheimer SY, Renner BA, Ekstrom A, Li Z, Henning SM, Brown JA, Jones M, Moody T, Small GW. Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Evid Based Complement Alternat Med. 2013;2013:946298.
138 Viggiano A, Viggiano A, Monda M, Turco I, Incarnato L, Vinno V, Viggiano E, Baccari ME, De Luca B. Annurca apple-rich diet restores long-term potentiation and induces behavioral modifications in aged rats. Exp Neurol. 2006 Jun;199(2):354-61.
139 Shukitt-Hale B, Kalt W, Carey AN, Vinqvist-Tymchuk M, McDonald J, Joseph JA. Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats.Nutrition. 2009 May;25(5):567-73.
140 Braidy N, Behzad S, Habtemariam S, Ahmed T, Daglia M, Nabavi SM, Sobarzo-Sanchez E, Nabavi SF. Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease. CNS Neurol Disord Drug Targets. 2017;16(4):387-397.
141 Ogunruku OO, Oboh G, Passamonti S, Trammer F, Boligon AA. Capsicum annuum var. grossum (Bell Pepper) Inhibits β-Secretase Activity and β-Amyloid1- 40 Aggregation. J Med Food. 2017 Feb;20(2):124-130.
142 PengY,HouC,YangZ,LiC,JiaL,LiuJ,TangY,ShiL,LiY,LongJ,LiuJ. Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 2016 Nov;60(11):2331-2342.
143 Killeen MJ, Linder M, Pontoniere P, Crea R. NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities. Drug Discov Today. 2014 Apr;19(4):373-8.
144 Daccache A, Lion C, Sibille N, Gerard M, Slomianny C, Lippens G, Cotelle P. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int. 2011 May;58(6):700-7.
145 Lee YM, Han SI, Song BC, Yeum KJ. Bioactives in Commonly Consumed Cereal Grains: Implications for Oxidative Stress and Inflammation. J Med Food. 2015 Nov;18(11):1179-86.
146 Chen X, Huang Y, Cheng HG. Lower intake of vegetables and legumes associated with cognitive decline among illiterate elderly Chinese: a 3-year cohort study. J Nutr Health Aging. 2012;16(6):549-52.
147 Barbour JA, Howe PR, Buckley JD, Bryan J, Coates AM. Nut consumption for vascular health and cognitive function. Nutr Res Rev. 2014 Jun;27(1):131-58.

8

148 Klimova B, Kuca K, Valis M, Hort J. Role of Nut Consumption in the Management of Cognitive Decline - A Mini-Review. Curr Alzheimer Res. 2018 Feb 1.
149 Arab L, Ang A. A cross sectional study of the association between walnut consumption and cognitive function among adult US populations represented in NHANES. J Nutr Health Aging. 2015 Mar;19(3):284-90.
150 Poulose SM, Miller MG, Shukitt-Hale B. Role of walnuts in maintaining brain health with age. J Nutr. 2014 Apr;144(4 Suppl):561S-566S.
151 Bahaeddin Z, Yans A, Khodagholi F, Hajimehdipoor H, Sahranavard S. Hazelnut and neuroprotection: Improved memory and hindered anxiety in response to intra-hippocampal Aβ injection. Nutr Neurosci. 2017 Jul;20(6):317-326.
152 Cardoso BR, Busse AL, Hare DJ, Cominetti C, Horst MA, McColl G, Magaldi RM, Jacob-Filho W2, Cozzolino SM. Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake. Food Funct. 2016 Feb;7(2):825-33.
153 Gao S, Jin Y, Hall KS, Liang C, Unverzagt FW, Ji R, Murrell JR, Cao J, Shen J, Ma F, Matesan J, Ying B, Cheng Y, Bian J, Li P, Hendrie HC. Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol. 2007 Apr 15;165(8):955-65.
154 Gorji N, Moeini R, Memariani Z. Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents. Pharmacol Res. 2018 Mar;129:115-127.
155 Obermann KR, Morris JC, Roe CM. Exploration of 100 commonly used drugs and supplements on cognition in older adults. Alzheimers Dement. 2013 Nov;9(6):724-32.
156 Keowkase R, Shoomarom N, Bunargin W, Sitthithaworn W, Weerapreeyakul N. Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans. Biomed Pharmacother. 2018 Aug 14;107:656-664.
157 Psalms 104:14. King James Version of the Bible.
158 Occhiuto F, Zangla G, Samperi S, Palumbo DR, Pino A, De Pasquale R, Circosta C. The phytoestrogenic isoflavones from Trifolium pratense L. (Red clover) protects human cortical neurons from glutamate toxicity. Phytomedicine. 2008 Sep;15(9):676-82.
159 Ahmad Rather M, Justin Thenmozhi A, Manivasagam T, Nataraj J, Essa MM, Chidambaram SB. Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease. Front Biosci (Elite Ed). 2018 Jan 1;10:287-299.
160 Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytother Res. 2009 Jan;23(1):14-9.
161 Heo JH, Park MH, Lee JH. Effect of Korean Red Ginseng on Cognitive Function and Quantitative EEG in Patients with Alzheimer's Disease: A Preliminary Study. J Altern Complement Med. 2016 Apr;22(4):280-5.
162 Li H, Sun X, Yu F, Xu L, Miu J, Xiao P. In Silico Investigation of the Pharmacological Mechanisms of Beneficial Effects of Ginkgo biloba L. on Alzheimer's Disease. Nutrients. 2018 May 10;10(5).
163 Ha GT, Wong RK, Zhang Y. Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies. Chem Biodivers. 2011 Jul;8(7):1189-204.
164 Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003 Feb;28(1):53-9.
165 Gillette Guyonnet S, Andrieu S, Vellas B. The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders. J Nutr Health Aging. 2007 Mar-Apr;11(2):119-24.
166 Bae D, Seol H, Yoon HG, Na JR, Oh K, Choi CY, Lee DW, Jun W, Youl Lee K, Lee J, Hwang K, Lee YH, Kim S. Inhaled essential oil from Chamaecyparis obtuse ameliorates the impairments of cognitive function induced by injection of β- amyloid in rats. Pharm Biol. 2012 Jul;50(7):900-10.
167 Millán González A, Martínez García R, Serrano Parra D, Nieto López M. Influence of oral intake of water in improving memory and visual acuity. Nutr Hosp. 2015 Dec 1;32 Suppl 2:10319.
168 Sawka MN, Cheuvront SN, Carter R 3rd. Human water needs. Nutr Rev. 2005 Jun;63(6 Pt 2):S30-9.
169 Koike Y, Kondo H, Kondo S, Takagi M, Kano Y. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study. Clin Interv Aging. 2013;8:543-8.
170 Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA. Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men. Age Ageing. 2017 Mar 1;46(2):245-249.
171 Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T. Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community. J Am Geriatr Soc. 2018 Jun 6.
172 Minakawa EN, Miyazaki K, Maruo K, Yagihara H, Fujita H, Wada K, Nagai Y. Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer's disease model mice. Neurosci Lett. 2017 Jul 13;653:362-369.
173 Crispim CA, Zimberg IZ, dos Reis BG, Diniz RM, Tufik S, de Mello MT. Relationship between food intake and sleep pattern in healthy individuals. J Clin Sleep Med. 2011 Dec 15;7(6):659-64.
174 Klegeris A, Schulzer M, Harper DG, McGeer PL. Increase in core body temperature of Alzheimer's disease patients as a possible indicator of chronic neuroinflammation: a meta-analysis. Gerontology. 2007;53(1):7-11.
175 Driver HS, Shulman I, Baker FC, Buffenstein R. Energy content of the evening meal alters nocturnal body temperature but not sleep. Physiol Behav. 1999 Dec 1- 15;68(1-2):17-23.

176 Dollander M. Etiology of adult insomniaEncephale. 2002 Nov-Dec;28(6 Pt 1):493-502.
177 Nie L, Wei G, Peng S, Qu Z, Yang Y, Yang Q, Huang X, Liu J, Zhuang Z, Yang X. Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease. Biofactors. 2017 Jul 8;43(4):593-611.

178 Gao HX, Zhang LX. Antagonistic effects of melatonin on glutamate-induced neurotoxicity in rat hippocampal neurons. Sheng Li Xue Bao. 1999 Aug;51(4):430- 4.
179 Lindstrom HA, Fritsch T, Petot G, Smyth KA, Chen CH, Debanne SM, Lerner AJ, Friedland RP. The relationships between television viewing in midlife and the development of Alzheimer's disease in a case-control study. Brain Cogn. 2005 Jul;58(2):157-65.
180 Wang JY, Zhou DH, Li J, Zhang M, Deng J, Tang M, Gao C, Li J, Lian Y, Chen M. Leisure activity and risk of cognitive impairment: the Chongqing aging study. Neurology. 2006 Mar 28;66(6):911-3.
181 Sobel E, Dunn M, Davanipour Z, Qian Z, Chui HC. Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure. Neurology. 1996 Dec;47(6):1477-81.
182 Del Giudice E, Facchinetti F, Nofrate V, Boccaccio P, Minelli T, Dam M, Leon A, Moschini G. Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma. Neurosci Lett. 2007 May 11;418(1):9-12.
183 Jalilian H, Teshnizi SH, Röösli M, Neghab M. Occupational exposure to extremely low frequency magnetic fields and risk of Alzheimer disease: A systematic review and meta-analysis. Neurotoxicology. 2017 Dec 24.
184 Särkämö T, Tervaniemi M, Laitinen S, Numminen A, Kurki M, Johnson JK, Rantanen P. Cognitive, emotional, and social benefits of regular musical activities in early dementia: randomized controlled study. Gerontologist. 2014 Aug;54(4):634-50.
185 Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H. Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003 Jun 19;348(25):2508-16.
186 Palisson J, Roussel-Baclet C, Maillet D, Belin C, Ankri J, Narme P. Music enhances verbal episodic memory in Alzheimer's disease. J Clin Exp Neuropsychol. 2015;37(5):503-17.
187 Russell-Williams J, Jaroudi W, Perich T, Hoscheidt S, El Haj M, Moustafa AA. Mindfulness and meditation: treating cognitive impairment and reducing stress in dementia. Rev Neurosci. 2018 Feb 21.
188 Last N, Tufts E, Auger LE. The Effects of Meditation on Grey Matter Atrophy and Neurodegeneration: A Systematic Review. J Alzheimers Dis. 2017;56(1):275- 286.
189 Psalms 119:97. King James Version of the Bible.
190 Yang SY, Shan CL, Qing H, Wang W, Zhu Y, Yin MM, Machado S, Yuan TF, Wu T. The Effects of Aerobic Exercise on Cognitive Function of Alzheimer's Disease Patients. CNS Neurol Disord Drug Targets. 2015;14(10):1292-7.
191 Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Hayashida N, Asada- Utsugi M, Watanabe K, Uemura M, Kihara T, Takahashi R, Shimohama S, Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J Biol Chem. 2012 Jun 29;287(27):23024-33.
192 Geda YE, Roberts RO, Knopman DS, Christianson TJ, Pankratz VS, Ivnik RJ, Boeve BF, Tangalos EG, Petersen RC, Rocca WA. Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol. 2010 Jan;67(1):80-6.
193 Winchester J, Dick MB, Gillen D, Reed B, Miller B, Tinklenberg J, Mungas D, Chui H, Galasko D, Hewett L, Cotman CW. Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):96-103.
194 Varma VR, Chuang YF, Harris GC, Tan EJ, Carlson MC. Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus. 2015 May;25(5):605-15.
195 Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. Walking and dementia in physically capable elderly men. JAMA. 2004 Sep 22;292(12):1447-53.
196 Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF. Neurodegenerative and neurological disorders by small inhaled particles. Neurotoxicology. 2016 Sep;56:94-106.
197 Park JS, Yoon CH. The effects of outdoor air supply rate on work performance during 8-h work period. Indoor Air. 2011 Aug;21(4):284-90.
198 Baron RA. Effects of negative ions on cognitive performance.J Appl Psychol. 1987 Feb;72(1):131-7.
199 Kornhuber HH. Prevention of dementia (including Alzheimer's disease).Gesundheitswesen. 2004 May;66(5):346-51.
200 Hartig T, Evansb GW, Jamnerc LD, Davisd DS, Gärlinge T. Tracking restoration in natural and urban field settings. J Environ Psych 2003 23(2):109-23. 201 Hughes TM, Sink KM. Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens. 2016 Feb;29(2):149-57.
202 Glodzik L, Mosconi L, Tsui W, de Santi S, Zinkowski R, Pirraglia E, Rich KE, McHugh P, Li Y, Williams S, Ali F, Zetterberg H, Blennow K, Mehta P, de Leon MJ. Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly. Neurobiol Aging. 2012 Jul;33(7):1215-27.
203 Câmara AB, de Souza ID, Dalmolin RJS. Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease. J Med Food. 2018 Mar 22.

9

204 Sommer I, Griebler U, Kien C, Auer S, Klerings I, Hammer R, Holzer P, Gartlehner G. Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis. BMC Geriatr. 2017 Jan 13;17(1):16.
205 Karssemeijer EGA, Aaronson JA, Bossers WJ, Smits T, Olde Rikkert MGM, Kessels RPC. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis. Ageing Res Rev. 2017 Nov;40:75-83.

206 Gill DP, Gregory MA, Zou G, Liu-Ambrose T, Shigematsu R, Hachinski V, Fitzgerald C, Petrella RJ. The Healthy Mind, Healthy Mobility Trial: A Novel Exercise Program for Older Adults. Med Sci Sports Exerc. 2016 Feb;48(2):297- 306.

207 Boyle PA, Buchman AS, Wilson RS, Yu L, Schneider JA, Bennett DA. Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age. Arch Gen Psychiatry. 2012 May;69(5):499- 505.
208 Boyle PA, Buchman AS, Barnes LL, Bennett DA. Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community- dwelling older persons. Arch Gen Psychiatry. 2010 Mar;67(3):304-10.
209 Ecclesiastes 9:10. King James Version of the Bible.
210 Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O'Neil JP, Wilson RS, Jagust WJ. Association of lifetime cognitive engagement and low β-amyloid deposition. Arch Neurol. 2012 May;69(5):623-29.
211 Wilson RS, Boyle PA, Yu L, Barnes LL, Schneider JA, Bennett DA. Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology. 2013 Jul 23;81(4):314-21.
212 Scalco MZ, van Reekum R. Prevention of Alzheimer disease. Encouraging evidence. Can Fam Physician. 2006 Feb;52:200-7.
213 Perls TT, Silver MH, Lauerman JF. Living to 100: Lessons In Living to Your Maximum Potential at Any Age. Basic Books (New York, NY), 1999, p. 157.
214 Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H. Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003 Jun 19;348(25):2508-16.
215 Scarmeas N, Levy G, Tang MX, Manly J, Stern Y. Influence of leisure activity on the incidence of Alzheimer's disease. Neurology. 2001 Dec 26;57(12):2236-42. 216 Berezuk C, Zakzanis KK, Ramirez J, Ruocco AC, Edwards JD, Callahan BL, Black SE. Functional Reserve: Experience Participating in Instrumental Activities of Daily Living is Associated with Gender and Functional Independence in Mild Cognitive Impairment. J Alzheimers Dis. 2017;58(2):425-434.
217 Hampstead BM, Sathian K, Bikson M, Stringer AY. Combined mnemonic strategy training and high-definition transcranial direct current stimulation for memory deficits in mild cognitive impairment. Alzheimers Dement (N Y). 2017 May 15;3(3):459-470.
218 Rosi A, Del Signore F, Canelli E, Allegri N, Bottiroli S, Vecchi T, Cavallini E. The effect of strategic memory training in older adults: who benefits most? Int Psychogeriatr. 2017 Dec 7:1-8.
219 Lee PL. A Joyful Heart is Good Medicine: Positive Affect Predicts Memory Complaints. Am J Geriatr Psychiatry. 2016 Aug;24(8):662-670.
220 Yang H, Yang S, Isen AM. Positive affect improves working memory: implications for controlled cognitive processing. Cogn Emot. 2013;27(3):474-82. 221 Brose A, Lövdén M, Schmiedek F. Daily fluctuations in positive affect positively co-vary with working memory performance. Emotion. 2014 Feb;14(1):1- 6.
222 Proverbs 17:22. King James Version of the Bible.
223 Simard M, Hudon C, van Reekum R. Psychological distress and risk for dementia. Curr Psychiatry Rep. 2009 Feb;11(1):41-7.
224 Machado A, Herrera AJ, de Pablos RM, Espinosa-Oliva AM, Sarmiento M, Ayala A, Venero JL, Santiago M, Villarán RF, Delgado-Cortés MJ, Argüelles S, Cano J. Chronic stress as a risk factor for Alzheimer's disease. Rev Neurosci. 2014;25(6):785-804.
225 Wilson RS, Evans DA, Bienias JL, Mendes de Leon CF, Schneider JA, Bennett DA. Proneness to psychological distress is associated with risk of Alzheimer's disease. Neurology. 2003 Dec 9;61(11):1479-85.
226 Gallagher D, Kiss A, Lanctot K, Herrmann N. Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry. 2018 Aug;26(8):819-827.
227 Burke SL, Cadet T, Alcide A, O'Driscoll J, Maramaldi P. Psychosocial risk factors and Alzheimer's disease: the associative effect of depression, sleep disturbance, and anxiety. Aging Ment Health. 2017 Oct 27:1-8.
228 Wang YP, Zhai JB, Zhu F, Zhang WW, Yang XJ, Qu CY. A three-year follow- up study on the transfer of mild cognitive impairment to Alzheimer's disease among the elderly in Taiyuan city. Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Feb;32(2):105-9.
229 Kropiunigg U, Sebek K, Leonhardsberger A, Schemper M, Dal-Bianco P. Psychosocial risk factors for Alzheimer's disease. Psychother Psychosom Med Psychol. 1999 May;49(5):153-9.
230 Galatians 5:22. The King James Version of the Bible.
231 Lin KP, Chou YC, Chen JH, Chen CD, Yang SY, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Religious affiliation and the risk of dementia in Taiwanese elderly. Arch Gerontol Geriatr. 2015 May-Jun;60(3):501-6.
232 Paganini-Hill A, Kawas CH, Corrada MM. Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study. Alzheimer Dis Assoc Disord. 2016 Jan- Mar;30(1):21-6.
233 Shimanuki H, Honda H, Ito T, Kasai T, Takato J, Sakamoto Y, Inuzuka G, Ito Y, Arayama N, Ueki S, Haga H. Relationships between volunteerism and social- physical health and QOL with community-dwelling elderly participating in a long-

term care prevention programme. Nihon Koshu Eisei Zasshi. 2007 Nov;54(11):749-59.
234 Ball LJ, Birge SJ. Prevention of brain aging and dementia. Clin Geriatr Med. 2002 Aug;18(3):485-503.
235 Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS. The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006 May;5(5):406-12.
236 White, E. G. (1898). The Desire of Ages. Mountain View, CA: Pacific Press Publishing Association. p. 330-1.